The UK Health Security Agency (UKHSA) has announced the launch of a large-scale human biomonitoring study. As part of the project, specialists will analyse blood and urine samples from volunteers to determine the concentration of perfluoroalkyl and polyfluoroalkyl substances (PFAS), as well as a range of other chemicals encountered by residents of the country. PFAS is a group of synthetic chemicals widely used in industry and consumer products, including water-repellent coatings, food packaging, and non-stick coatings for cookware. These substances have earned the nickname "forever chemicals" due to their ability to break down extremely slowly in the environment and accumulate in the human body. Research links prolonged exposure to PFAS with various health problems, raising growing concern among regulators worldwide. The goal of UKHSA's new study is to obtain reliable data on the levels of chemical exposure in the UK population. The information obtained should fill gaps in knowledge about the extent of contact between residents and such compounds and serve as a scientific basis for subsequent research in the field of public health. Biomonitoring results are planned to be used in developing recommendations and policy decisions aimed at reducing potential health risks to the population. Similar programmes are already being implemented in a number of other countries, including the USA and EU states, where biomonitoring has become a standard tool for assessing chemical exposure in the human body. UKHSA emphasises that the study is long-term in nature and will form the basis for systematic monitoring of changes in the level of chemical exposure among British residents in the future.